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HTR2A Gene Changes Found Only in Progressive MS May Be New Biomarker

Scientists have discovered epigenetic changes in a gene called HTR2A, found only in immune cells isolated from people with secondary progressive multiple sclerosis (SPMS), a study reported. These findings suggest that such changes — external modifications to DNA that turn genes “on” or “off” — may be a potential biomarker for progressive MS, the researchers said. The details were published in the journal Nature Scientific Reports, in the study “Epigenetic differences at the HTR2A locus…