Cholesterol Metabolism Impaired in CF Mouse Model

Cholesterol Metabolism Impaired in CF Mouse Model

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Cholesterol Metabolism Impaired in CF Mouse Model

The metabolism of cholesterol is impaired in a mouse model of cystic fibrosis, a preliminary study suggests. In the model, there seems to be an altered production of bile salts (those that help with the digestion of fats) that may reduce the digestion and/or absorption of cholesterol. This increases cholesterol’s synthesis by the liver and leads to its accumulation within cells, triggering inflammation and feeding the cycle of altered bile salt production. The study, “Impaired cholesterol…

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